Diazon Cream Mechanism of Action

Pharmacology: Fungistatic; may be fungicidal and sporocidal, depending on concentration. Ketoconazole inhibits biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane and altering its permeability; as a result, loss of essential intracellular elements may occur. It also inhibits biosynthesis of triglycerides and phospholipids by fungi. In addition, it inhibits oxidative and peroxidative enzyme activity, resulting in intracellular buildup of toxic concentrations of hydrogen peroxide, which may contribute to deterioration of subcellular organelles and cellular necrosis. In the treatment of Candida albicans, inhibits transformation of blastospores into invasive mycelial form.
Pharmacokinetics: Absorption: After a single topical application of ketoconazole cream to the chest, back and arms of normal volunteers, systemic absorption of ketoconazole was detected during the following 72-hr period, using a minimum detection level of 5 ng/mL in blood.